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Fig. 5 | Cancer & Metabolism

Fig. 5

From: In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells

Fig. 5

a Immunohistochemical staining of the bone marrow for CD138+ clonal plasma cells in MM patient #2 with primary plasma cell leukemia as well as peripheral smear evaluation demonstrating the presence of circulating plasma cells. b Positron emission tomography-computed tomography (PET/CT) demonstrating the presence of a large plasmacytoma in the right chest wall as well as immunohistochemical staining of the bone marrow for CD138+ clonal plasma cells in MM patient #7 with no marrow involvement. c Graphical visualization of the concentrations of the TCA cycle intermediate such as glutamate, succinate, fumarate, malate, and aspartate in the bone marrow plasma of MM patient #2 with primary plasma cell leukemia and MM patient #7 with respect to that of the remainder of the MM patients (represented by the mean (dashed line) and maximum and minimum (dotted lines) values)

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Cancer & Metabolism

ISSN: 2049-3002