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Fig. 4 | Cancer & Metabolism

Fig. 4

From: In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells

Fig. 4

a Violin plots comparing the median concentrations of different TCA metabolites in the bone marrow plasma between MGUS (N = 11) and MM (N = 12) groups. Data was analyzed by Mann-Whitney U test where ***p < 0.001, **p < 0.01, *p < 0.05, #p < 0.1 but ≥ 0.05, n.s. non-significant. b Violin plots comparing the median concentrations of different TCA metabolites in the peripheral blood plasma between MGUS (N = 11) and MM (N = 12) groups. Data was analyzed by Mann-Whitney U test where ***p < 0.001, **p < 0.01, *p < 0.05, #p < 0.1 but ≥ 0.05, n.s. non-significant. c Violin plots comparing the median concentrations of aspartate and glutamate in the bone marrow plasma between the volunteers (N = 7), MGUS (N = 11), and MM (N = 12) groups. Data was analyzed by Mann-Whitney U test where ***p < 0.001, **p < 0.01, *p < 0.05, #p < 0.1 but ≥ 0.05, n.s. non-significant. d XY-correlation plots comparing the concentrations of aspartate and glutamate in the bone marrow plasma of patients with MGUS and MM and the percentage of clonal plasma cells in their bone marrow

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