Fig. 2

a Glutamine enrichment in bone marrow plasma after 60 min of the [¹³C₅]-glutamine infusion in patients with MGUS (N = 11) and MM (N = 12). Error bars represent SEM. n.s. is non-significant by unpaired t test. b Comparison of mean relative ¹³C fractional enrichment of TCA cycle intermediates in CD138+ and CD138- cells from the bone marrows of MGUS (N = 10) and MM (N = 11). Error bars represent SEM. n.s. is non-significant, *p < 0.05, **p < 0.01, and ***p < 0.001 by paired t test. c Relative ¹³C fractional enrichment (CD138+/CD138-) of TCA cycle intermediates from each MGUS (N = 10) and MM (N = 11) patient.