TY - JOUR AU - De Vitto, Humberto AU - Ryu, Joohyun AU - Calderon-Aparicio, Ali AU - Monts, Josh AU - Dey, Raja AU - Chakraborty, Abhijit AU - Lee, Mee-Hyun AU - Bode, Ann M. AU - Dong, Zigang PY - 2020 DA - 2020/12/10 TI - Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function JO - Cancer & Metabolism SP - 28 VL - 8 IS - 1 AB - Of the genes that control mitochondrial biogenesis and function, ERRĪ± emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes mutated in cancer, TP53 remains the most elusive to target. A clear understanding of how mitochondrial druggable targets can be accessed to exploit the underlying mechanism(s) explaining how p53-deficient tumors promote cell survival remains elusive. SN - 2049-3002 UR - https://doi.org/10.1186/s40170-020-00234-5 DO - 10.1186/s40170-020-00234-5 ID - De Vitto2020 ER -