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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate

Fig. 4

Protein synthesis inhibition drives TXNIP expression independent of oncogenic burden. TXNIP mRNA levels following a 16-h CHX treatment of a wildtype or HRAS(G12V)-expressing murine embryonic fibroblasts (MEFs), b TSC2−/− MEFs expressing empty vector or human-TSC2, and c MDA-MB-231 expressing tet-inducible MYC(T58A) with or without doxycyline. Immunoblots showing TXNIP, MondoA, and tubulin protein levels following 16-h RocA treatment of d HeLa cells, e MDA-MB-157 cells, and f MDA-MB-231 cells. TXNIP mRNA levels were determined using RT-qPCR

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