Fig. 6From: The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesisLevels of pyrimidines and purines at 24 h. a–i Peak areas of the reported metabolites in HAP1-ΔSHMT2 cells supplemented with different concentrations of formate, without or with rapamycin treatment. Quantifications are done relative to the Taurine peak area. Bars represent the mean and error bars the standard deviation from 3 independent experiments, each represented by the symbols. The p values shown were obtained using a t test with two tails and unequal varianceBack to article page