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Fig. 5 | Cancer & Metabolism

Fig. 5

From: The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis

Fig. 5

Incorporation of 15N into purines. a Schematic representation of the pathway of incorporation of 15N from [15N-amide]-glutamine into purine precursors and purines. b–f Peak areas of 15N purine precursors and purines in HAP1-ΔSHMT2 cells at different times and under different conditions. g Total ATP levels (14N+15N). Quantifications are done relative to the Taurine peak area. Bars represent the mean and error bars the standard deviation from 3 independent experiments, each represented by the symbols. The p values shown were obtained using a t test with two tails and unequal variance

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