TY - JOUR AU - Tait-Mulder, Jacqueline AU - Hodge, Kelly AU - Sumpton, David AU - Zanivan, Sara AU - Vazquez, Alexei PY - 2020 DA - 2020/09/21 TI - The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis JO - Cancer & Metabolism SP - 20 VL - 8 IS - 1 AB - Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it is not clear how formate induces pyrimidine synthesis. SN - 2049-3002 UR - https://doi.org/10.1186/s40170-020-00228-3 DO - 10.1186/s40170-020-00228-3 ID - Tait-Mulder2020 ER -