Fig. 7
From: Treatment of ErbB2 breast cancer by mitochondrial targeting
Suppression mTORC1 activity by MEDICA. a BT474 cells infected with empty or NDI1 virus were treated for 24 h with 150uM MEDICA as indicated. Representative blots. b, c BT474 cells infected with empty, shSestrin2, or shAMPK were treated for 28 h with MEDICA as indicated. Representative blots. d, e BT474 cells infected with control or shREDD1 were treated for 28 h with MEDICA as indicated. Representative blots. f Suppression of mitochondrial complex I activity by MEDICA results in suppression of mTORC1 activity and lipid raft disruption with loss of ErbB members. The double hit of MEDICA results in abrogating HER2 survival