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Fig. 1 | Cancer & Metabolism

Fig. 1

From: Treatment of ErbB2 breast cancer by mitochondrial targeting

Fig. 1

Suppression of ErbB2 breast cancer by MEDICA in vivo. ac FVB-MMTV-ErbB2 transgenic mice were treated by MEDICA in feed as described in the “Methods” section. *Significant as compared to nontreated. a Breast tumor number (left), weight (middle), and volume (right). Mean (n = 5–6/group). b Tumor ErbB1, ErbB2, phospho-ErbB2(Tyr1248), and ErbB3. Representative blots. c Lung rat ErbB2/neu (V664G) transcript. Mean (n = 9–11/group). d NOD/SCID mice xenografted with RH2111 ErbB2 cells were treated with MEDICA in feed as described in the “Methods” section. Tumor volume (left) and tumor weight (right). Mean ± SD (n = 4–5/group). Significant as compared to nontreated (P < 0.05)

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