Fig. 1
From: Tumor-associated collagen signatures: pushing tumor boundaries
a Schematic of a 3-dimensional tumor with quadrant missing, to highlight the location of TACS layers. b Zoomed in breakdown of TACS layers from internal to external, 1–3. Specifically, TACS1: increased collagen deposition around the tumor, TACS2: alignment of layers around the tumor in a spherical manner, TACS3: development of perpendicular tracts of collagen away from the tumor. c Hypothetical application of TACS3 in co-opting normal breast structure for invasion and metastasis. Image made using biorender.com