Skip to main content

Table 1 Prognostic impact of hypoxia score, UCP1, and FABP7

From: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

 

Univariate

Multivariate

HR

p-value

HR

p-value

METABRIC

 All cases (N = 1904)

  Hypoxia-score

1.30 (1.10-1.50)

<0.001***

1.43 (1.21-1.68)

<0.001***

  UCP1

0.94 (0.84-1.10)

0.27

0.96 (0.86-1.08)

0.515

  FABP7

0.99 (0.94-1.00)

0.504

0.95 (0.90-0.99)

0.02*

 ER+ (N = 1445)

  Hypoxia-score

1.40 (1.20-1.80)

<0.001***

1.47 (1.18-1.80)

<0.001***

  UCP1

0.99 (0.88-1.10)

0.908

1.01 (0.90-1.10)

0.875

  FABP7

0.97 (0.89-1.10)

0.558

0.94 (0.85-1.00)

0.214

 ER- (N = 429)

  Hypoxia-score

1.20 (0.88-1.60)

0.246

1.24 (0.89-1.70)

0.201

  UCP1

0.62 (0.28-1.40)

0.241

0.64 (0.29-1.40)

0.278

  FABP7

0.95 (0.90-1.00)

0.114

0.94 (0.88-1.00)

0.053

TCGA

 All cases (N = 960)

  hypoxia-score

1.50 (1.00-2.10)

0.028*

2.19 (1.46-3.28)

<0.001***

  UCP1

1.00 (0.92-1.10)

0.763

1.04 (0.95-1.14)

0.403

  FABP7

0.92 (0.87-0.97)

0.003**

0.89 (0.84-0.94)

<0.001***

 ER+ (N = 708)

  hypoxia-score

1.40 (0.80-2.40)

0.246

1.50 (0.80-2.64)

0.216

  UCP1

1.00 (0.94-1.20)

0.403

1.10 (0.96-1.16)

0.244

  FABP7

0.80 (0.71-0.89)

<0.001***

0.80 (0.72-0.89)

<0.001***

 ER- (N = 208)

  hypoxia-score

1.20 (0.57-2.6)

0.601

1.59 (0.71-3.50)

0.255

  UCP1

1.00 (0.58-1.80)

0.944

1.08 (0.60-1.90)

0.799

  FABP7

0.93 (0.86-1.00)

0.092

0.92 (0.84-1.00)

0.053

  1. *p < 0.05, **p < 0.01, and ***p < 0.001