| |
Univariate
|
Multivariate
|
|---|
|
HR
|
p-value
|
HR
|
p-value
|
|---|
|
METABRIC
|
|
All cases (N = 1904)
|
|
Hypoxia-score
|
1.30 (1.10-1.50)
|
<0.001***
|
1.43 (1.21-1.68)
|
<0.001***
|
|
UCP1
|
0.94 (0.84-1.10)
|
0.27
|
0.96 (0.86-1.08)
|
0.515
|
|
FABP7
|
0.99 (0.94-1.00)
|
0.504
|
0.95 (0.90-0.99)
|
0.02*
|
|
ER+ (N = 1445)
|
|
Hypoxia-score
|
1.40 (1.20-1.80)
|
<0.001***
|
1.47 (1.18-1.80)
|
<0.001***
|
|
UCP1
|
0.99 (0.88-1.10)
|
0.908
|
1.01 (0.90-1.10)
|
0.875
|
|
FABP7
|
0.97 (0.89-1.10)
|
0.558
|
0.94 (0.85-1.00)
|
0.214
|
|
ER- (N = 429)
|
|
Hypoxia-score
|
1.20 (0.88-1.60)
|
0.246
|
1.24 (0.89-1.70)
|
0.201
|
|
UCP1
|
0.62 (0.28-1.40)
|
0.241
|
0.64 (0.29-1.40)
|
0.278
|
|
FABP7
|
0.95 (0.90-1.00)
|
0.114
|
0.94 (0.88-1.00)
|
0.053
|
|
TCGA
|
|
All cases (N = 960)
|
|
hypoxia-score
|
1.50 (1.00-2.10)
|
0.028*
|
2.19 (1.46-3.28)
|
<0.001***
|
|
UCP1
|
1.00 (0.92-1.10)
|
0.763
|
1.04 (0.95-1.14)
|
0.403
|
|
FABP7
|
0.92 (0.87-0.97)
|
0.003**
|
0.89 (0.84-0.94)
|
<0.001***
|
|
ER+ (N = 708)
|
|
hypoxia-score
|
1.40 (0.80-2.40)
|
0.246
|
1.50 (0.80-2.64)
|
0.216
|
|
UCP1
|
1.00 (0.94-1.20)
|
0.403
|
1.10 (0.96-1.16)
|
0.244
|
|
FABP7
|
0.80 (0.71-0.89)
|
<0.001***
|
0.80 (0.72-0.89)
|
<0.001***
|
|
ER- (N = 208)
|
|
hypoxia-score
|
1.20 (0.57-2.6)
|
0.601
|
1.59 (0.71-3.50)
|
0.255
|
|
UCP1
|
1.00 (0.58-1.80)
|
0.944
|
1.08 (0.60-1.90)
|
0.799
|
|
FABP7
|
0.93 (0.86-1.00)
|
0.092
|
0.92 (0.84-1.00)
|
0.053
|
- *p < 0.05, **p < 0.01, and ***p < 0.001
