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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

Fig. 4

FABP7 knockdown (FABP7-Kd) increased oxygen consumption, proton leak, and glycolysis. a Oxygen consumption rate (OCR) curve of controls (Ctrl) and FABP7-Kd cells. Oligomycin (Oligo), FCCP, and rotenone/antimycin A (Rot/AA) were added sequentially. b Estimated mitochondrial basal respiration (upper left), maximal respiration (upper right), proton leak (lower left), and coupling efficacy (lower right) of Ctrl and FABP7-Kd. c Extracellular acidification rate (ECAR) curve of Ctrl and FABP7-Kd. Glucose (Glu), oligo, and 2-deoxy-glucose (2-DG) were added sequentially. d Estimated glycolysis and glycolytic capacity of Ctrl and FABP7-Kd. Error bars, SD; *p < 0.05, ***p < 0.001, ****p < 0.0001; n = 3. Each experiment consisted of 20 technical replicates for each condition

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Cancer & Metabolism

ISSN: 2049-3002