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Fig. 1 | Cancer & Metabolism

Fig. 1

From: Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells

Fig. 1

Genes expressed in the cell lines. a Heatmaps show global expression patterns. Left: heatmap representing mRNA levels. Right: heatmap representing RPF levels. Each column represents a cell line and each row an expressed gene. log2TMM-normalized values are plotted. The color code represents expression data levels: light shades of blue indicate low expression levels, while strong shades indicate high expression levels. b The biplot shows the log2 RPKM of RPFs (y-axis) and mRNA (x-axis) of genes expressed in MCF7 control, c MCF7 MKL1 ΔN200, and d MCF7 MKL1 ΔC301. The coefficient of determination is shown in black while the linear regression slopes are shown in violet. Gene groups are depicted in different colors: in red, genes with high transcription and low translation; in blue, genes with high transcription and very high translation; in green, genes with high transcription and translation. TMM, trimmed mean of M values; RPKM, reads per kilobase million

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Cancer & Metabolism

ISSN: 2049-3002