Fig. 3
From: Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model
13C-glutamine infusions in HOT-bearing mice. a MRI of representative mouse HOT derived from each parental primary culture (M1, M2, CNP1, CNP2). b HOT-bearing mice derived from each parental primary culture (M1, M2, CNP1, CNP2) were infused with 13C5-glutamine for the indicated times. The time course shows representative 13C-glutamine enrichment in plasma (%). All mice received a bolus of 13C5-glutamine over 1 min followed by a continuous 13C5-glutamine infusion. c, d Enrichment in 13C-glutamine (%) from independent samples for each tumor subtype (n = 4 to 10) after 300 min in the liver (c) and control cerebral hemisphere (d)