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Fig. 6 | Cancer & Metabolism

Fig. 6

From: Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Fig. 6

Labeling with multiple tracers shows that ~ 20% of pyruvate is generated from cysteine. Multi-tracer of 1,2-13C2-glucose, 5-13C1-glutamine, and 13C-cysteine labeling of intracellular metabolites in PHGDH/NPL dual knockout D7 PDAC cells following with vehicle (−Dox) or PKM1/2 knockdown (+Dox). The y-axis for all graphs is the percent labeling of indicated 13C-isotopologue. Experiments were performed in triplicates and all data are displayed as the mean values ± standard error

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Cancer & Metabolism

ISSN: 2049-3002