TY - JOUR AU - Yu, Lei AU - Teoh, Shao Thing AU - Ensink, Elliot AU - Ogrodzinski, Martin P. AU - Yang, Che AU - Vazquez, Ana I. AU - Lunt, Sophia Y. PY - 2019 DA - 2019/12/30 TI - Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells JO - Cancer & Metabolism SP - 13 VL - 7 IS - 1 AB - Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial. To investigate the role of pyruvate kinase in pancreatic cancer, we knocked down PKM2 individually as well as both PKM1 and PKM2 concurrently (PKM1/2) in cell lines derived from a KrasG12D/-; p53-/- pancreatic mouse model. SN - 2049-3002 UR - https://doi.org/10.1186/s40170-019-0205-z DO - 10.1186/s40170-019-0205-z ID - Yu2019 ER -