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Fig. 3 | Cancer & Metabolism

Fig. 3

From: SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia

Fig. 3

A controlled-release mitochondrial protonophore slows E0771 breast tumor growth in an insulin-dependent manner. a Liver triglyceride content. In all panels, unless otherwise specified, all mice were fasted for 5 h before they were studied. b, c Plasma glucose and insulin concentrations. d Tumor 2-deoxyglucose uptake and VPDH/VCS. f Tumor size. **P < 0.01 vs. chow, #P < 0.05, ##P < 0.01 vs. HFD + CRMP, with the color of the symbols indicating the group compared to the group designated by the symbols. In all panels, data are the mean ± S.E.M. of n = 5–6 per group. Groups were compared by ANOVA with Bonferroni’s multiple comparisons test

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