Fig 1
From: SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia
Dapagliflozin slows E0771 breast tumor growth in an insulin-dependent manner. a, b Urine and plasma glucose concentrations. Unless otherwise designated, all measurements were performed in 5-h fasted mice. c Plasma insulin. d, e Tumor 2-deoxyglucose uptake and VPDH/VCS. f Tumor size. *P < 0.05, ***P < 0.001, ****P < 0.0001 vs. chow, ++P < 0.01, ++++P < 0.0001 vs. HFD + dapagliflozin, with the color of the symbols indicating the group compared to the group designated by the symbols. In all panels, data are the mean ± S.E.M. of n = 5 per group. Groups were compared by ANOVA with Bonferroni’s multiple comparisons test