Table 3 Yeast-human homologs with deletion enhancement and UES across all tissues
From: A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin
hGene | yGene | DB | Fig. | GO term | HLD L|K | HLEG L|K | GDSC pval | gCSI pval | Ref | H | Description hGene |
|---|---|---|---|---|---|---|---|---|---|---|---|
ACTL6B | ARP4 | Both | 12E | Ino80 Complex | 8.3|− 10 | 16.4|− 12.6 | 3.3E−02 | 3.8E−02 | [172] | 2 | Actin like 6B |
HMGCS2 | ERG13 | Both | S7B | N/A | 34.8|− 21.4 | 3.7|− 3.3 | 2.4E−02 | 7.9E−04 | [186] | 2 | 3-Hydroxy-3-methylglutaryl-CoA synthase 2 |
PPM1L | PTC1 | Both | 12C | N/A | 15.2|− 4.7 | 14.7|− 13 | 3.1E−04 | 1.6E−02 | 2 | Protein phosphatase, Mg2+/Mn2+ dependent 1L | |
RPS6KB2 | SCH9 | Both | 12E | Sphingolipid Metabolic Process | 6|− 3.7 | 8.8|− 9.8 | 3.5E−02 | 4.2E−03 | NA | 3 | Ribosomal protein S6 kinase B2 |
SEC11C | SEC11 | Both | S7B | N/A | 11.6|− 1.3 | 2.8|0 | 3.5E−04 | 3.5E−04 | [175] | 2 | SEC11 homolog C, signal peptidase complex subunit |
ARFGEF2 | SEC7 | Both | 12C | N/A | 2.9|0 | 2.6|0.8 | 7.5E−03 | 1.5E−08 | 2 | ADP ribosylation factor guanine nucleotide exchange factor 2 | |
IQSEC3 | SEC7 | Both | 12C | N/A | 2.9|0 | 2.6|0.8 | 7.5E−03 | 4.9E−02 | NA | 2 | IQ motif and Sec7 domain 3 |
PPCDC | SIS2 | Both | 12C | N/A | 7.3|− 3.5 | 12.1|− 9.8 | 3.9E−02 | 4.7E−03 | NA | 2 | Phosphopantothenoylcysteine decarboxylase |
CCS | CCS1 | gCSI | NA | N/A | 2.4|− 0.4 | 5.6|− 3.7 | 3.4E−01 | 1.2E−02 | NA | 2 | Copper chaperone for superoxide dismutase |
HMGCS1 | ERG13 | gCSI | S7B | N/A | 34.8|− 21.4 | 3.7|− 3.3 | 9.5E−01 | 1.4E−02 | [185] | 3 | 3-Hydroxy-3-methylglutaryl-CoA synthase 1 |
HDAC6 | HDA1 | gCSI | 7A | HDA1 Complex | 5.2|− 1 | 9.1|− 1.8 | 9.1E−01 | 1.7E−03 | 2 | Histone deacetylase 6 | |
MUS81 | MUS81 | gCSI | 8B | DNA Topological Change | 5.2|− 2.4 | 15.9|− 11.1 | 6.9E−02 | 1.9E−04 | 2 | MUS81 structure-specific endonuclease subunit | |
SGK2 | SCH9 | gCSI | 12E | Sphingolipid Metabolic Process | 6|− 3.7 | 8.8|− 9.8 | 4.6E−01 | 8.5E−04 | NA | 1 | SGK2, serine/threonine kinase 2 |
CCS | SOD1 | gCSI | 12E | N/A | 6.2|− 0.5 | 8.1|− 10.7 | 3.4E−01 | 1.2E−02 | NA | 2 | Copper chaperone for superoxide dismutase |
SOD1 | SOD1 | GDSC | 12E | N/A | 6.2|− 0.5 | 8.1|− 10.7 | 4.3E−02 | 7.9E−01 | NA | 2 | Superoxide dismutase 1 |
PELO | DOM34 | gCSI | 9A | Dom34-Hbs1 Complex | 2.5|− 0.7 | − 1.2|1.1 | NA | 1.7E−02 | NA | 2 | Pelota mRNA surveillance and ribosome rescue factor |
ADH1A | SFA1 | gCSI | 12E | N/A | 4.8|0 | 0.9|− 0.3 | 1.1E−01 | 2.9E−02 | 2 | Alcohol dehydrogenase 1A (class I), alpha polypeptide | |
ADH4 | SFA1 | gCSI | 12E | N/A | 4.8|0 | 0.9|− 0.3 | 3.6E−01 | 3.6E−03 | [184] | 3 | Alcohol dehydrogenase 4 (class II), pi polypeptide |
ADH6 | SFA1 | gCSI | 12E | N/A | 4.8|0 | 0.9|− 0.3 | 8.6E−01 | 3.3E−03 | [183] | 1 | Alcohol dehydrogenase 6 (class V) |
HIST1H3D | HHT1 | Both | 6A-B | Nucleosome Assembly | 0.4|− 0.2 | 15|− 10.2 | 4.2E−02 | 2.1E−02 | NA | 2 | Histone cluster 1 H3 family member d |
HIST1H2BN | HTB1 | Both | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | 4.0E−02 | 3.0E−06 | NA | 2 | Histone cluster 1 H2B family member n |
HIST2H2BE | HTB1 | Both | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | 4.0E−02 | 2.3E−08 | NA | 2 | Histone cluster 2 H2B family member e |
SETBP1 | SET2 | Both | 6A,C | Histone exchange | 1.3|− 1.6 | 5.4|− 2.5 | 7.3E−07 | 3.0E−04 | NA | 3 | SET binding protein 1 |
RNF40 | BRE1 | gCSI | 7C | Histone Monoubiquitination | − 0.7|0.5 | 6.5|− 4.9 | 7.4E−01 | 8.5E−03 | NA | 2 | Ring finger protein 40 |
HIST1H4D | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | NA | 8.9E−03 | NA | 3 | Histone cluster 1 H4 family member d |
HIST1H4H | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | 8.6E−02 | 2.8E−06 | NA | 3 | Histone cluster 1 H4 family member h |
HIST1H4I | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | NA | 3.8E−02 | NA | 2 | Histone cluster 1 H4 family member i |
HIST1H4K | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | NA | 8.0E−03 | NA | 3 | Histone cluster 1 H4 family member k |
HIST2H4A | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | NA | 4.8E−02 | NA | 3 | Histone cluster 2 H4 family member a |
HIST2H4B | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | NA | 3.7E−03 | NA | 3 | Histone cluster 2 H4 family member b |
HIST4H4 | HHF1 | gCSI | 6A-B | Nucleosome Assembly | − 0.6|0.2 | 13.7|− 3.8 | 5.4E−02 | 2.4E−02 | NA | 3 | Histone cluster 4 H4 |
HIST1H4D | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | NA | 8.9E−03 | NA | 3 | Histone cluster 1 H4 family member d |
HIST1H4H | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | 8.6E−02 | 2.8E−06 | NA | 3 | Histone cluster 1 H4 family member h |
HIST1H4I | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | NA | 3.8E−02 | NA | 3 | Histone cluster 1 H4 family member i |
HIST1H4K | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | NA | 8.0E−03 | NA | 3 | Histone cluster 1 H4 family member k |
HIST2H4A | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | NA | 4.8E−02 | NA | 3 | Histone cluster 2 H4 family member a |
HIST2H4B | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | NA | 3.7E−03 | NA | 3 | Histone cluster 2 H4 family member b |
HIST4H4 | HHF2 | gCSI | 12E | Chromatin Assembly or Disassembly | − 1.6|0.4 | 4.3|− 0.1 | 5.4E−02 | 2.4E−02 | NA | 3 | Histone cluster 4 H4 |
HIST1H2AE | HHT1 | gCSI | 6A-B | Nucleosome Assembly | 0.4|− 0.2 | 15|− 10.2 | NA | 1.1E−02 | NA | 3 | Histone cluster 1 H2A family member e |
HIST1H3E | HHT1 | gCSI | 6A-B | Nucleosome Assembly | 0.4|− 0.2 | 15|− 10.2 | NA | 1.3E−02 | NA | 3 | Histone cluster 1 H3 family member e |
HIST1H3H | HHT1 | gCSI | 6A-B | Nucleosome Assembly | 0.4|− 0.2 | 15|− 10.2 | NA | 6.8E−03 | NA | 3 | Histone cluster 1 H3 family member h |
HIST1H2AC | HTA1 | gCSI | 12E | Chromatin Assembly or Disassembly | − 3.5|0.8 | 13.5|− 5.2 | 7.1E−01 | 2.9E−05 | NA | 3 | Histone cluster 1 H2A family member c |
HIST1H2AD | HTA1 | gCSI | 12E | Chromatin Assembly or Disassembly | − 3.5|0.8 | 13.5|− 5.2 | 3.7E−01 | 5.8E−03 | NA | 3 | Histone cluster 1 H2A family member d |
HIST1H2AG | HTA1 | gCSI | 12E | Chromatin Assembly or Disassembly | − 3.5|0.8 | 13.5|− 5.2 | 5.6E−01 | 1.4E−02 | NA | 3 | Histone cluster 1 H2A family member g |
HIST1H2AK | HTA1 | gCSI | 12E | Chromatin Assembly or Disassembly | − 3.5|0.8 | 13.5|− 5.2 | NA | 6.3E−04 | NA | 3 | Histone cluster 1 H2A family member k |
HIST2H2AA3 | HTA1 | gCSI | 12E | Chromatin Assembly or Disassembly | − 3.5|0.8 | 13.5|− 5.2 | NA | 2.6E−02 | NA | 3 | Histone cluster 2 H2A family member a3 |
HIST2H2AA4 | HTA1 | gCSI | 12E | Chromatin Assembly or Disassembly | − 3.5|0.8 | 13.5|− 5.2 | NA | 5.3E−03 | NA | 3 | Histone cluster 2 H2A family member a4 |
H2BFM | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | NA | 3.0E−02 | NA | 3 | H2B histone family member M |
H2BFWT | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | 3.3E−01 | 6.5E−04 | NA | 3 | H2B histone family member W, testis specific |
HIST1H2BC | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | 9.8E−01 | 5.3E−05 | NA | 3 | Histone cluster 1 H2B family member c |
HIST1H2BD | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | 4.7E−01 | 3.0E−06 | NA | 3 | Histone cluster 1 H2B family member d |
HIST1H2BE | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | NA | 2.5E−04 | NA | 3 | Histone cluster 1 H2B family member e |
HIST1H2BF | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | NA | 5.3E−03 | NA | 3 | Histone cluster 1 H2B family member f |
HIST1H2BG | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | NA | 5.8E−04 | NA | 3 | Histone cluster 1 H2B family member g |
HIST1H2BJ | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | 9.2E−02 | 1.5E−03 | NA | 3 | Histone cluster 1 H2B family member j |
HIST1H2BK | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | NA | 9.0E−04 | NA | 3 | Histone cluster 1 H2B family member k |
HIST1H2BO | HTB1 | gCSI | 6A-B | Nucleosome Assembly | 0.2|− 0.6 | 7.8|− 5.8 | NA | 2.9E−02 | NA | 3 | Histone cluster 1 H2B family member o |
NAA30 | MAK3 | gCSI | 8A | NatC Complex | 0.2|− 0.5 | 16.6|− 11.6 | 8.5E−01 | 2.9E−02 | [180] | 2 | N (alpha)-acetyltransferase 30, NatC catalytic subunit |
ROMO1 | MGR2 | gCSI | S3C | Protein import into mitochondrial matrix | 0|− 0.2 | 10.3|0.1 | 7.1E−02 | 4.1E−02 | 2 | Reactive oxygen species modulator 1 | |
AIRE | RCO1 | gCSI | 7A | Rpd3S Complex | 0.9|− 0.5 | 7.9|− 4.4 | 5.5E−01 | 1.3E−03 | NA | 3 | Autoimmune regulator |
ASH1L | SET2 | gCSI | 6A,C | Histone exchange | 1.3|− 1.6 | 5.4|− 2.5 | 6.6E−01 | 5.5E−04 | NA | 3 | ASH1 like histone lysine methyltransferase |
RECQL4 | SGS1 | gCSI | 8B | DNA Topological Change | − 0.2|0.7 | 6.1|− 2.5 | 7.3E−01 | 3.2E−02 | NA | 3 | RecQ like helicase 4 |
RECQL5 | SGS1 | gCSI | 8B | DNA Topological Change | − 0.2|0.7 | 6.1|− 2.5 | 2.7E−01 | 3.0E−04 | NA | 1 | RecQ like helicase 5 |
SRCAP | SWR1 | gCSI | 7A | Swr1 complex | 0.4|− 0.5 | 7.3|− 6.2 | NA | 5.1E−04 | NA | 3 | Snf2 related CREBBP activator protein |
UNC45B | TOM70 | gCSI | S3C | Protein import into mitochondrial matrix | 0.8|− 0.4 | 12.4|− 0.3 | 7.4E−01 | 1.6E−02 | NA | 2 | unc-45 myosin chaperone B |
MOCS3 | UBA4 | gCSI | 8A | protein urmylation | 1.5|− 3.3 | 8.1|− 3.4 | 8.0E−01 | 3.0E−02 | NA | 1 | Molybdenum cofactor synthesis 3 |
EMC3 | EMC3 | GDSC | 8A | ER Membrane Protein Complex | 1.5|− 0.8 | 5.6|− 1.8 | 1.1E−02 | NA | NA | 2 | ER membrane protein complex subunit 3 |
EMC4 | EMC4 | GDSC | 8A | ER Membrane Protein Complex | − 0.1|− 0.3 | 6.2|− 1.6 | 2.6E−02 | NA | NA | 2 | ER membrane protein complex subunit 4 |