Skip to main content

Table 3 Yeast-human homologs with deletion enhancement and UES across all tissues

From: A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin

hGene yGene DB Fig. GO term HLD L|K HLEG L|K GDSC pval gCSI pval Ref H Description hGene
ACTL6B ARP4 Both 12E Ino80 Complex 8.3|− 10 16.4|− 12.6 3.3E−02 3.8E−02 [172] 2 Actin like 6B
HMGCS2 ERG13 Both S7B N/A 34.8|− 21.4 3.7|− 3.3 2.4E−02 7.9E−04 [186] 2 3-Hydroxy-3-methylglutaryl-CoA synthase 2
PPM1L PTC1 Both 12C N/A 15.2|− 4.7 14.7|− 13 3.1E−04 1.6E−02 [173, 174] 2 Protein phosphatase, Mg2+/Mn2+ dependent 1L
RPS6KB2 SCH9 Both 12E Sphingolipid Metabolic Process 6|− 3.7 8.8|− 9.8 3.5E−02 4.2E−03 NA 3 Ribosomal protein S6 kinase B2
SEC11C SEC11 Both S7B N/A 11.6|− 1.3 2.8|0 3.5E−04 3.5E−04 [175] 2 SEC11 homolog C, signal peptidase complex subunit
ARFGEF2 SEC7 Both 12C N/A 2.9|0 2.6|0.8 7.5E−03 1.5E−08 [176, 177] 2 ADP ribosylation factor guanine nucleotide exchange factor 2
IQSEC3 SEC7 Both 12C N/A 2.9|0 2.6|0.8 7.5E−03 4.9E−02 NA 2 IQ motif and Sec7 domain 3
PPCDC SIS2 Both 12C N/A 7.3|− 3.5 12.1|− 9.8 3.9E−02 4.7E−03 NA 2 Phosphopantothenoylcysteine decarboxylase
CCS CCS1 gCSI NA N/A 2.4|− 0.4 5.6|− 3.7 3.4E−01 1.2E−02 NA 2 Copper chaperone for superoxide dismutase
HMGCS1 ERG13 gCSI S7B N/A 34.8|− 21.4 3.7|− 3.3 9.5E−01 1.4E−02 [185] 3 3-Hydroxy-3-methylglutaryl-CoA synthase 1
HDAC6 HDA1 gCSI 7A HDA1 Complex 5.2|− 1 9.1|− 1.8 9.1E−01 1.7E−03 [235, 236] 2 Histone deacetylase 6
MUS81 MUS81 gCSI 8B DNA Topological Change 5.2|− 2.4 15.9|− 11.1 6.9E−02 1.9E−04 [181, 182] 2 MUS81 structure-specific endonuclease subunit
SGK2 SCH9 gCSI 12E Sphingolipid Metabolic Process 6|− 3.7 8.8|− 9.8 4.6E−01 8.5E−04 NA 1 SGK2, serine/threonine kinase 2
CCS SOD1 gCSI 12E N/A 6.2|− 0.5 8.1|− 10.7 3.4E−01 1.2E−02 NA 2 Copper chaperone for superoxide dismutase
SOD1 SOD1 GDSC 12E N/A 6.2|− 0.5 8.1|− 10.7 4.3E−02 7.9E−01 NA 2 Superoxide dismutase 1
PELO DOM34 gCSI 9A Dom34-Hbs1 Complex 2.5|− 0.7 − 1.2|1.1 NA 1.7E−02 NA 2 Pelota mRNA surveillance and ribosome rescue factor
ADH1A SFA1 gCSI 12E N/A 4.8|0 0.9|− 0.3 1.1E−01 2.9E−02 [183, 184] 2 Alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH4 SFA1 gCSI 12E N/A 4.8|0 0.9|− 0.3 3.6E−01 3.6E−03 [184] 3 Alcohol dehydrogenase 4 (class II), pi polypeptide
ADH6 SFA1 gCSI 12E N/A 4.8|0 0.9|− 0.3 8.6E−01 3.3E−03 [183] 1 Alcohol dehydrogenase 6 (class V)
HIST1H3D HHT1 Both 6A-B Nucleosome Assembly 0.4|− 0.2 15|− 10.2 4.2E−02 2.1E−02 NA 2 Histone cluster 1 H3 family member d
HIST1H2BN HTB1 Both 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 4.0E−02 3.0E−06 NA 2 Histone cluster 1 H2B family member n
HIST2H2BE HTB1 Both 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 4.0E−02 2.3E−08 NA 2 Histone cluster 2 H2B family member e
SETBP1 SET2 Both 6A,C Histone exchange 1.3|− 1.6 5.4|− 2.5 7.3E−07 3.0E−04 NA 3 SET binding protein 1
RNF40 BRE1 gCSI 7C Histone Monoubiquitination − 0.7|0.5 6.5|− 4.9 7.4E−01 8.5E−03 NA 2 Ring finger protein 40
HIST1H4D HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 NA 8.9E−03 NA 3 Histone cluster 1 H4 family member d
HIST1H4H HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 8.6E−02 2.8E−06 NA 3 Histone cluster 1 H4 family member h
HIST1H4I HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 NA 3.8E−02 NA 2 Histone cluster 1 H4 family member i
HIST1H4K HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 NA 8.0E−03 NA 3 Histone cluster 1 H4 family member k
HIST2H4A HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 NA 4.8E−02 NA 3 Histone cluster 2 H4 family member a
HIST2H4B HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 NA 3.7E−03 NA 3 Histone cluster 2 H4 family member b
HIST4H4 HHF1 gCSI 6A-B Nucleosome Assembly − 0.6|0.2 13.7|− 3.8 5.4E−02 2.4E−02 NA 3 Histone cluster 4 H4
HIST1H4D HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 NA 8.9E−03 NA 3 Histone cluster 1 H4 family member d
HIST1H4H HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 8.6E−02 2.8E−06 NA 3 Histone cluster 1 H4 family member h
HIST1H4I HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 NA 3.8E−02 NA 3 Histone cluster 1 H4 family member i
HIST1H4K HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 NA 8.0E−03 NA 3 Histone cluster 1 H4 family member k
HIST2H4A HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 NA 4.8E−02 NA 3 Histone cluster 2 H4 family member a
HIST2H4B HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 NA 3.7E−03 NA 3 Histone cluster 2 H4 family member b
HIST4H4 HHF2 gCSI 12E Chromatin Assembly or Disassembly − 1.6|0.4 4.3|− 0.1 5.4E−02 2.4E−02 NA 3 Histone cluster 4 H4
HIST1H2AE HHT1 gCSI 6A-B Nucleosome Assembly 0.4|− 0.2 15|− 10.2 NA 1.1E−02 NA 3 Histone cluster 1 H2A family member e
HIST1H3E HHT1 gCSI 6A-B Nucleosome Assembly 0.4|− 0.2 15|− 10.2 NA 1.3E−02 NA 3 Histone cluster 1 H3 family member e
HIST1H3H HHT1 gCSI 6A-B Nucleosome Assembly 0.4|− 0.2 15|− 10.2 NA 6.8E−03 NA 3 Histone cluster 1 H3 family member h
HIST1H2AC HTA1 gCSI 12E Chromatin Assembly or Disassembly − 3.5|0.8 13.5|− 5.2 7.1E−01 2.9E−05 NA 3 Histone cluster 1 H2A family member c
HIST1H2AD HTA1 gCSI 12E Chromatin Assembly or Disassembly − 3.5|0.8 13.5|− 5.2 3.7E−01 5.8E−03 NA 3 Histone cluster 1 H2A family member d
HIST1H2AG HTA1 gCSI 12E Chromatin Assembly or Disassembly − 3.5|0.8 13.5|− 5.2 5.6E−01 1.4E−02 NA 3 Histone cluster 1 H2A family member g
HIST1H2AK HTA1 gCSI 12E Chromatin Assembly or Disassembly − 3.5|0.8 13.5|− 5.2 NA 6.3E−04 NA 3 Histone cluster 1 H2A family member k
HIST2H2AA3 HTA1 gCSI 12E Chromatin Assembly or Disassembly − 3.5|0.8 13.5|− 5.2 NA 2.6E−02 NA 3 Histone cluster 2 H2A family member a3
HIST2H2AA4 HTA1 gCSI 12E Chromatin Assembly or Disassembly − 3.5|0.8 13.5|− 5.2 NA 5.3E−03 NA 3 Histone cluster 2 H2A family member a4
H2BFM HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 NA 3.0E−02 NA 3 H2B histone family member M
H2BFWT HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 3.3E−01 6.5E−04 NA 3 H2B histone family member W, testis specific
HIST1H2BC HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 9.8E−01 5.3E−05 NA 3 Histone cluster 1 H2B family member c
HIST1H2BD HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 4.7E−01 3.0E−06 NA 3 Histone cluster 1 H2B family member d
HIST1H2BE HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 NA 2.5E−04 NA 3 Histone cluster 1 H2B family member e
HIST1H2BF HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 NA 5.3E−03 NA 3 Histone cluster 1 H2B family member f
HIST1H2BG HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 NA 5.8E−04 NA 3 Histone cluster 1 H2B family member g
HIST1H2BJ HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 9.2E−02 1.5E−03 NA 3 Histone cluster 1 H2B family member j
HIST1H2BK HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 NA 9.0E−04 NA 3 Histone cluster 1 H2B family member k
HIST1H2BO HTB1 gCSI 6A-B Nucleosome Assembly 0.2|− 0.6 7.8|− 5.8 NA 2.9E−02 NA 3 Histone cluster 1 H2B family member o
NAA30 MAK3 gCSI 8A NatC Complex 0.2|− 0.5 16.6|− 11.6 8.5E−01 2.9E−02 [180] 2 N (alpha)-acetyltransferase 30, NatC catalytic subunit
ROMO1 MGR2 gCSI S3C Protein import into mitochondrial matrix 0|− 0.2 10.3|0.1 7.1E−02 4.1E−02 [178, 179] 2 Reactive oxygen species modulator 1
AIRE RCO1 gCSI 7A Rpd3S Complex 0.9|− 0.5 7.9|− 4.4 5.5E−01 1.3E−03 NA 3 Autoimmune regulator
ASH1L SET2 gCSI 6A,C Histone exchange 1.3|− 1.6 5.4|− 2.5 6.6E−01 5.5E−04 NA 3 ASH1 like histone lysine methyltransferase
RECQL4 SGS1 gCSI 8B DNA Topological Change − 0.2|0.7 6.1|− 2.5 7.3E−01 3.2E−02 NA 3 RecQ like helicase 4
RECQL5 SGS1 gCSI 8B DNA Topological Change − 0.2|0.7 6.1|− 2.5 2.7E−01 3.0E−04 NA 1 RecQ like helicase 5
SRCAP SWR1 gCSI 7A Swr1 complex 0.4|− 0.5 7.3|− 6.2 NA 5.1E−04 NA 3 Snf2 related CREBBP activator protein
UNC45B TOM70 gCSI S3C Protein import into mitochondrial matrix 0.8|− 0.4 12.4|− 0.3 7.4E−01 1.6E−02 NA 2 unc-45 myosin chaperone B
MOCS3 UBA4 gCSI 8A protein urmylation 1.5|− 3.3 8.1|− 3.4 8.0E−01 3.0E−02 NA 1 Molybdenum cofactor synthesis 3
EMC3 EMC3 GDSC 8A ER Membrane Protein Complex 1.5|− 0.8 5.6|− 1.8 1.1E−02 NA NA 2 ER membrane protein complex subunit 3
EMC4 EMC4 GDSC 8A ER Membrane Protein Complex − 0.1|− 0.3 6.2|− 1.6 2.6E−02 NA NA 2 ER membrane protein complex subunit 4
  1. For column “DB”: “gCSI,” “GDSC”, or “Both” indicate UES in the gCSI, GDSC, or both databases. Column “Fig.” refers to specific figures. Columns “HLD L|K” and “HLEG L|K” contain the L and K interaction scores for HLD and HLEG media, respectively. “GDSC pval” and “gCSI pval” refer to the significance of differential gene expression in the respective databases. “Ref” refers to relevant literature citations. “H” refers to homology type: “1,” “2,” and “3” indicate 1:1, 1:many, and many:many, respectively