Table 1 GO Terms enriched in REMc clusters

Resp

Enh

5.0

2.8

1-0-7

nucleosome organization

1.1E−07

VPS71 RSC2 SWR1 LDB7 HHF1 RSC4 IES1 ISW1 ARP6 RTT106 HIR3 SWC3 HPC2 YAF9 HIR1 HIR2 HTB1 NHP6A SWC5 NHP10

Resp

Enh

7.1

0.1

1-0-7

Set1C/COMPASS complex

5.5E−04

SPP1 SDC1 SWD1 SWD3 BRE2

Resp

Enh

3.9

− 0.6

1-0-7

histone methylation

4.1E−03

SPP1 SDC1 LGE1 NOP1 SWD3 HHF1 SWD1 BRE2

Resp

Enh

3.4

3.0

1-0-7

protein import into mitochondrial matrix

6.4E−03

MGR2 TOM7 YME1 TOM70 PAM17 TIM17 TIM23 TOM6

Resp

Enh

0.6

0.8

2-0.7-1

ER membrane protein complex

4.6E−06

EMC6 EMC4 EMC3 EMC5

Resp

Enh

4.6

0.2

2-0.7-2

Sin3-type complex

1.5E−05

RCO1 RXT2 SAP30 PHO23 DEP1 UME1

Resp

Enh

5.2

− 0.1

2-0.7-2

Rpd3L complex

7.1E−05

RXT2 SAP30 PHO23 DEP1 UME1

Resp

Enh

7.3

1.6

2-0.7-2

Swr1 complex

1.2E−06

SWC3 SWC5 VPS71 YAF9 SWR1 ARP6

Resp

Enh

5.9

2.1

2-0.7-2

histone exchange

5.7E−06

SWC3 SWC5 VPS71 YAF9 SWR1 ARP6

Resp

Enh

5.0

3.4

2-0.7-2

ATP-dependent chromatin remodeling

2.4E−04

SWC3 SWC5 VPS71 YAF9 SWR1 LDB7 ARP6

Resp

Enh

11.9

0.2

2-0.7-2

HIR complex

6.6E−06

HPC2 HIR1 HIR3 HIR2

Resp

Enh

11.4

3.2

2-0.7-2

DNA replication-independent nucleosome assembly

4.5E−04

HPC2 HIR1 HIR3 HIR2

Resp

Enh

11.0

1.7

1-0-8

respiratory chain complex III assembly

4.2E−02

QCR9 CBP4 FMP25

Resp

Enh

7.9

0.7

2-0.8-0

DNA topological change

2.6E−02

TOP3 MUS81

Resp

Enh

14.9

− 0.4

2-0.8-1

NatC complex

5.6E−03

MAK31 MAK3

Resp

Sup

− 2.6

− 1.5

2-0.3-1

regulation of fatty acid beta-oxidation

2.1E−02

ADR1 OAF1 PIP2

Resp

Sup

− 0.3

6.7

2-0.3-5

translation reinitiation

2.0E−02

TMA20 TIF34 TMA22

Glyc

Enh

1.1

0.5

2-0.2-2

ribonucleoprotein complex subunit organization

1.9E−02

RSA4 HBS1 BRR1 SDO1 RPS17A DHH1 CLF1 RRP7 TIF6 RPS14A RPS27B PRP9

Glyc

Sup

− 2.2

− 3.0

2-0.4-0

7-methylguanosine cap hypermethylation

5.6E−03

SWM2 TGS1

Glyc

Sup

1.5

− 0.4

2-0.4-2

mRNA 3'-end processing

8.6E−04

MPE1 CDC73 YSH1 KIN28 RNA14 NRD1

Glyc

Sup

1.3

0.9

2-0.4-2

mRNA cleavage

3.3E−02

MPE1 YSH1 POP8 RNA14

Glyc

Sup

− 0.8

− 2.9

2-0.4-2

meiotic chromosome condensation

3.4E−03

SMC2 YCG1 YCS4

Glyc

Sup

− 1.0

− 2.7

2-0.4-2

condensin complex

2.8E−03

SMC2 YCG1 YCS4

Both

Enh

2.9

2.3

1-0-6

cellular response to DNA damage stimulus

4.1E−08

CTK3 SIT4 RTT109 RVB1 RAD54 MMS22 CDC1 RAD55 PSF3 RAD50 BUD25 RAD51 MRE11 ARP8 ARP4 RAD57 TFB1 CDC7 RAD52 NPL6

Both

Enh

5.0

5.0

1-0-6

double-strand break repair via homologous recombination

2.9E−07

PSF3 RAD50 RAD51 MRE11 RAD54 MMS22 RAD57 CDC7 RAD52 RAD55

Both

Enh

7.7

9.7

1-0-6

double-strand break repair via synthesis-dependent strand annealing

4.3E−06

RAD54 RAD57 RAD51 RAD52 MRE11 RAD55

Both

Enh

9.2

5.0

2-0.6-1

ATP-dependent 3'-5' DNA helicase activity

1.9E−04

RVB1 ARP5 ARP8 ARP4

Both

Enh

9.0

2.5

2-0.6-1

Ino80 complex

2.1E−05

RVB1 IES6 ARP5 ARP8 ARP4

Both

Enh

3.4

1.6

2-0.6-1

histone acetylation

4.1E−02

RTT109 RVB1 NGG1 SPT20 ARP4

Resp

Enh

7.4

1.1

2-0.2-1

protein urmylation

1.1E−03

URM1 URE2 UBA4 ELP2

Both

Enh

9.9

3.9

2-0.2-1

Lst4-Lst7 complex

3.1E−02

LST7 LST4

Both

Sup

− 4.5

− 2.3

2-0.4-1

cellular sphingolipid homeostasis

9.6E−05

VPS53 VPS52 VPS54 VPS51

Both

Sup

− 12.2

− 7.0

2-0.4-1

fatty acid elongase activity

2.9E−02

ELO3 ELO2

Both

Sup

− 3.0

− 1.3

2-0.4-1

actin cortical patch localization

8.1E−03

RVS167 LSB3 RVS161 VRP1

Both

Sup

− 9.0

− 3.5

2-0.4-1

Rvs161p-Rvs167p complex

1.7E−02

RVS167 RVS161

Both

Sup

− 4.4

− 0.6

2-0.4-1

telomere tethering at nuclear periphery

1.8E−02

NUP60 MLP1 NUP120 NUP133