Fig. 12

Yeast phenomic model for the influence of Warburg metabolism on doxorubicin-gene interaction. Shaded areas indicate influences that are relatively Warburg-dependent, being red or green if their effects are relatively specific to a respiratory or glycolytic context, respectively. Processes that influence doxorubicin cytotoxicity in a more Warburg-independent manner are unshaded. Arrowheads indicate processes for which genes predominantly transduce doxorubicin toxicity, based on their loss of function suppressing its growth inhibitory effects. Conversely, a perpendicular bar at the line head indicates a process that buffers doxorubicin toxicity, as genetic compromise of its function enhances the growth inhibitory effects of doxorubicin