Fig. 3From: Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancerPEPCKi decreases proliferation in colorectal cancer cells. a–f Colo205, Ls180, Ls174T, HT29, SW180, and HCT116 cells, respectively, were treated with PEPCKi and cell number determined. g HT29 cells stably expressing an empty vector or PEPCK were treated with indicated doses of PEPCKi and cell number determined. h Colo205 cells with shNT or shPEPCK were treated 10 μM PEPCKi and cell number determined. Cells were seeded and treated with indicated doses of inhibitor for up to 5 days. N = 3 ± SD. *p < 0.05, **p < 0.01Back to article page