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Fig. 2 | Cancer & Metabolism

Fig. 2

From: Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC

Fig. 2

SDHC gene expression in subgroups of breast cancer. The two cohorts included in the study was subdivided based on molecular characteristics such as estrogen receptor positive and negative (ER+ and ER−) and basal- and non-basal phenotype. Claudin-low and triple negative subgroups were included in the basal category. In addition, the breast cancer patient cohort (n = 204) was subgrouped based on histology, i.e., into ducal and lobular characteristics. a mRNA expression of SDHC and b EMT8 signature were assessed for the distinct subgroups in the n = 204 cohort. c mRNA expression of SDHC and d EMT8 and EMT315 signatures were determined for the subgroups in the n = 3992 Affymetrix meta cohort. e Spearman correlation analysis for SDHC expression relative to EMT8 signature for subgroups of the breast cancer cohort (n = 204) and f the Affymetrix meta cohort. g Kaplan-Meier survival plots for basal- (n = 42) and non-basal-like (n = 161) breast carcinoma of the breast cancer cohort. The gene expression data are displayed with relative arbitrary units

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