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Table 2 Ingenuity canonical pathways associated with the proteins identified as differentially expressed between MCF7Ecadvar and MCF7pcDNA3 cells. Results obtained with the IPA tool

From: Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an increased expression of lactate dehydrogenase B

Ingenuity canonical pathways -log(p value) Proteins involved
Glycolysis 0.0836 G6PI, TPIS, PGAM1, F16P1, ALDOA
Gluconeogenesis 0.0827 G6PI, PGAM1, F16P1, ALDOA, MAOX
Protein ubiquitination pathway 0.0535 PSB3, PSA6, HS90B, GRP75, HS71A, HS71B, HS90A, UBA1
14–3-3-mediated signaling 0.0486 1433 T, GRB2, PDIA3, 1433Z, VIME
p70S6K signaling 0.0483 1433 T, GRB2, PDIA3, EF2, 1433Z
PI3K/AKT signaling 0.0478 1433 T, HS90B, GRB2, 1433Z, HS90A
Pentose phosphate pathway (oxidative branch) 0.0439 6PGL, G6PD
Aldosterone signaling in epithelial cells 0.0431 HS90B, PDIA3, GRP75, HS71A, HS71B, HS90A
PPARα/RXRα activation 0.0413 HS90B, GRB2, GPDM, PDIA3, HS90A
Glucocorticoid receptor signaling 0.0410 HS90B, GRB2, ACTB, GRP75, HS71A, HS71B, HS90A
  1. List of the ten canonical pathways most altered in MCF7Ecadvar cells compared with MCF7pcDNA3. They were ordered in a descending form according to the number of the negative of the logarithm of the p value assigned to each of them. The symbol of the proteins identified with differential expression levels between both cell lines that were involved in each pathway are also indicated in the table. PPARα peroxisome proliferator-activated receiver α, RXRα retinoid X receiver α