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Fig. 5 | Cancer & Metabolism

Fig. 5

From: CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

Fig. 5

CHCHD4 loss reduces tumour cell sensitivity to CI inhibitors. a Graph shows relative growth of U2OS cells stably expressing shRNA control or CHCHD4 shRNA (CHCHD4 shRNA1) cultured in normoxia or hypoxia in either glucose or glucose-free (galactose) containing media for 72 h. n = 3, mean ± SD, n.s. not significant, *p < 0.05, **p < 0.01. b Graphs show relative growth of cells described in a culture in normoxia and hypoxia (1% O2) for 24 h in the absence and presence of BAY 87-2243 at the concentrations indicated, incubated in glucose or glucose-free (galactose) containing media. Data are presented as BAY 87-2243-treated relative to untreated (0 nM). n = 2, mean ± SD, **p < 0.01, ***p < 0.001

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