Fig. 1
From: Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells
Transport-exclusion pharmacology to localize enzyme activity within a cell. a When the enzyme is localized to the cytosol, both inhibitors block activity. b When the enzyme is localized to mitochondria, only IS blocks activity. E represents the enzyme of interest localized in cytosol or mitochondria. IS represents an inhibitor of E that is transported into mitochondria. IB represents an inhibitor of E that cannot be transported into mitochondria