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Fig. 3 | Cancer & Metabolism

Fig. 3

From: Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer

Fig. 3

Exercise-responsive tumors demonstrate distinct metabolic differences. a Volcano plot showing fold changes in metabolites between control and exercise groups in the three exercise-responsive PDX models. Significantly altered metabolites (p < 0.05) determined using paired Student’s t test. b Heat map of integrated intensity values of the significantly altered metabolites between responsive control and exercise groups. c Corresponding impacted pathways as determined by the 15 significantly altered metabolites. dh Key metabolic pathways broken down by individual metabolites. Error bars are representative of standard error of mean (SEM). * indicates p < 0.05, paired Student’s t test

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