Fig. 1
From: Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice
Dietary restriction improves obese leukemic C57BL/6J mouse survival after vincristine treatment. a Scheme showing diet intervention in survival experiments. b Survival of mice with ALL in each diet group with no chemotherapy treatment (n = 12/group). c Survival of mice with ALL in each diet group treated with VCR. ▼ indicate VCR doses. Vehicle-treated mice were distributed evenly between all three diet groups, and were combined due to no difference in survival. N = 12/group; **p < 0.01, ***p < 0.001, log rank. d Body weight of mice on each diet. e Total (left), carbohydrate (center), and fat (right) calorie daily intake in mice from each diet group. Intake is shown as daily average up until day 5 after the diet switch, and as 3 point moving average thereafter, due to high day-to-day variability. Standard deviations reflect variance between 2 and 4 cages, not individual mice. Since protein content was identical between diets, the relative intake was proportional to total caloric intake and not shown separately