Fig. 2

PKM2 deletion in PDAC tumors does not affect mouse survival, tumor weight, or tumor histology. a Kaplan-Meier curve showing survival of the KP^−/−C Pkm2^+/+ and KP^−/−C Pkm2^flox/flox mouse cohorts. No statistically significant difference in survival was observed between the two cohorts (n = 24 Pkm2^flox/flox mice, 25 Pkm2^+/+ mice per cohort, p = 0.3862, log-rank (Mantel-Cox) test). b The weight of tumors isolated from end-stage KP^−/−C Pkm2^+/+ and KPC Pkm2^flox/flox mice, and the percentage of the tumor weight relative to whole body weight is shown. c Hematoxylin and eosin (H&E) staining of PDAC tumors from KP^−/−C Pkm2^+/+ and KP^−/−C Pkm2^flox/flox mice. d PCR genotyping of the PKM2 allele in tumors arising in KP^−/−C Pkm2^+/+ and KP^−/−C Pkm2^flox/flox mice is shown. Analysis of tail DNA from Pkm2^+/+ and PKM2^flox/flox mice is also shown as a control