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Fig. 2 | Cancer & Metabolism

Fig. 2

From: PKM2 is not required for pancreatic ductal adenocarcinoma

Fig. 2

PKM2 deletion in PDAC tumors does not affect mouse survival, tumor weight, or tumor histology. a Kaplan-Meier curve showing survival of the KP−/−C Pkm2+/+ and KP−/−C Pkm2flox/flox mouse cohorts. No statistically significant difference in survival was observed between the two cohorts (n = 24 Pkm2flox/flox mice, 25 Pkm2+/+ mice per cohort, p = 0.3862, log-rank (Mantel-Cox) test). b The weight of tumors isolated from end-stage KP−/−C Pkm2+/+ and KPC Pkm2flox/flox mice, and the percentage of the tumor weight relative to whole body weight is shown. c Hematoxylin and eosin (H&E) staining of PDAC tumors from KP−/−C Pkm2+/+ and KP−/−C Pkm2flox/flox mice. d PCR genotyping of the PKM2 allele in tumors arising in KP−/−C Pkm2+/+ and KP−/−C Pkm2flox/flox mice is shown. Analysis of tail DNA from Pkm2+/+ and PKM2flox/flox mice is also shown as a control

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