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Fig. 6 | Cancer & Metabolism

Fig. 6

From: Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation

Fig. 6

Comparison of consequences of CRISPR knockout and RNAi knockdown of MTHFD2. a Pearson correlation and global rank between MTHFD2 and genes involved in folate metabolism in shRNA and CRISPR screens. b Comparison of growth effects caused by depletion of MTHFD2 and SHMT2 using shRNA and CRISPR in Achilles project. Each circle represents a tested cell line. Pearson’s correlation is shown. c Distribution of correlations between growth phenotype effects of all examined genes and MTHFD2 across 14 AML cell lines. Selected genes involved in one-carbon metabolism are indicated by arrows

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Cancer & Metabolism

ISSN: 2049-3002