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Fig. 5 | Cancer & Metabolism

Fig. 5

From: Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation

Fig. 5

Consequences of MTHFD2 knockdown. a Enrichment plot showing ranks of the D2PPI gene set among 12,328 genes responding to treatment with MTHFD2 shRNA in CMap study. Overall enrichment score was − 0.64. Genes with low enrichment scores (histones and RSP5) are indicated. b Distribution of enrichment scores for 3582 gene sets, with arrow indicating position of D2PPI gene set. c Heatmap showing connectivity scores for all 510 genes with significant associations (scores > 90 or < − 90) in CMap project with either of MTHFD2, MTHFD1 or SHMT2. Genes were clustered by average linkage and Pearson correlation distance. d Connectivity scores between MTHFD2, MTHFD1, and SHMT2 with ribosomal genes measured in the CMap project

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