Fig. 3

MTHFD2-interacting proteins are coexpressed with MTHFD2 in response to stimuli. a Enrichment plot showing the ranks of MTHFD2-interacting (D2PPI) proteins ordered by overall coexpression with MTHFD2 across 8067 gene expression data sets (see Methods). b Heat map of coexpression score for the D2PPI and ATF4 gene sets, across the 50 data sets exhibiting with strongest coexpression for each set. Data sets selected for panels c–f are indicated by arrows. c–f Heat maps of expression level for selected data sets. For each gene, ratio over the overall mean is shown, according to scale bars. Only genes with nonzero coexpression scores are shown. MTHFD2 expression level is shown above in linear scale, with baseline equal to zero (arbitrary units)