Fig. 5

2-HG, acting via HIF-1α, downregulates PC and PE synthesis in the BT54 patient-derived IDHmut glioma model. Effect of AGI-5198 on PC (a), PE (b), CKα expression (c), CK activity (d), EK activity (e), and HIF-1α (f) in the BT54 model. g Representative western blots showing silencing of HIF-1α in the BT54 model. Effect of HIF-1α silencing on PC (h), PE (i), CKα expression (j), CK activity (k), and EK activity (l) in the BT54 model