Fig. 3From: Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner2-HG is responsible for the downregulation of PC and PE synthesis in IDHmut glioma cells. PC (a), PE (b), CKα expression (c), CK activity (d), and EK activity (e) in NHAIDHwt cells, NHAIDHwt cells incubated with 2-HG, NHAIDHmut cells, and NHAIDHmut cells treated with AGI-5198Back to article page