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Fig. 5 | Cancer & Metabolism

Fig. 5

From: Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state

Fig. 5

Proposed model of study on impact of leptin on melanoma growth and the outcome of dacarbazine therapy. Leptin modulates FASN and Hsp90 levels while resistin modulates Cav-1 and P-gp, thereby enhancing melanoma growth. Collectively, these events are responsible in part for impaired outcome of DTIC therapy. Inhibition of these molecules restricts melanoma growth and improves the outcome of chemotherapy

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Cancer & Metabolism

ISSN: 2049-3002