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Table 1 Survival prediction in human patients using model-specific metabolites

From: Metabolomics of oncogene-specific metabolic reprogramming during breast cancer

Value for met signature (no. of metabolites in signature) P value (10) P value (9) P value (8) P value (7) Metabolites used in COX proportional hazard model
Normal 0.002 0.001 0.003 0.01 Citrate; nicotinamide adenine dinucleotide (NAD+); gamma-glutamyltyrosine; S-adenosylhomocysteine (SAH); glycerophosphorylcholine (GPC); gamma-glutamylglutamate; choline phosphate; ribose; mannitol$; Isobar: ribulose 5-phosphate#, xylulose 5-phosphate*
Wnt1 0.79 0.786 0.72 0.63 2-Linoleoylglycerophosphoethanolamine; glycylleucine; margarate (17:0); creatine; 10-nonadecenoate (19:1n9); threonate; cytidine 5′-diphosphocholine; eicosenoate (20:1n9 or 11)$; lysine#; 2-hydroxyglutarate*
Neu 0.82 0.746 0.65 0.55 2-Linoleoylglycerophosphoethanolamine; N-acetylaspartate (NAA); pipecolate; glycerol 3-phosphate (G3P); dihomo-linoleate (20:2n6); dihomo-linolenate (20:3n3 or n6); stearoyl sphingomyelin; N6-acetyllysine$; trans-4-hydroxyproline#; docosapentaenoate (n3 DPA; 22:5n3)*
C3-TAg 0.009 0.03 0.02 0.02 Gamma-glutamyltyrosine; choline phosphate; Isobar: ribulose 5-phosphate, xylulose 5-phosphate; ribitol; gamma-glutamylalanine; thymine; maltotriose; ribulose$; choline#; 5-oxoproline*
PyMT 0.05 0.04 0.07 0.04 Gamma-glutamyltyrosine; S-adenosylhomocysteine (SAH); choline phosphate; stearoylcarnitine; phenyllactate (PLA); Isobar: ribulose 5-phosphate, xylulose 5-phosphate; cystine; N-acetylaspartate (NAA)$; gamma-glutamylalanine#; 2-hydroxyglutarate*
PyMT-DB 0.61 0.57 0.48 0.37 Ribose; maltose; margarate (17:0); 10-nonadecenoate (19:1n9); maltotriose; cytidine 5′-diphosphocholine; urea; glutathione, oxidized (GSSG)$; oleate (18:1n9)#; 10-heptadecenoate (17:1n7)*
  1. P values were calculated by fitting a Cox proportional hazard model using survival times as output and the indicated metabolites as input. P values that are < 0.05 are italicized
  2. *The metabolite not included in the 9 metabolite signature. See also Additional file 9
  3. #The metabolite not included in the 8 metabolite signature. See also Additional file 9
  4. $The metabolite not included in the 7 metabolite signature. See also Additional file 9