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Fig. 3 | Cancer & Metabolism

Fig. 3

From: PKM2 is not required for colon cancer initiated by APC loss

Fig. 3

PKM2 expression is lost in colon tumor cells in Pkm2 conditional animals. a Tissue sections from tumors arising in Apc flox/flox Pkm2 +/+ mice were stained with hematoxylin and eosin (H&E) or with antibodies against PKM2, PKM1, or β-catenin as shown. b Colon tumors arising in Apc flox/flox Pkm2 flox/flox mice were stained with hematoxylin and eosin (H&E) or with antibodies against PKM2, PKM1, or β-catenin as shown. A PKM2 negative region that switches to PKM1 expression is marked with an arrowhead, and a PKM2 positive region is marked with an arrow. Scale bars represent 50 μm for all images at ×20 magnification (top row in each panel) and 20 μm for all images at ×40 magnification (bottom row in each panel)

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