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Fig. 2 | Cancer & Metabolism

Fig. 2

From: PKM2 is not required for colon cancer initiated by APC loss

Fig. 2

PKM2 deletion does not affect tumor penetrance, multiplicity, or survival in mice with APC deletion. a Colon tumors were initiated in Apc flox/flox Pkm2 +/+ and Apc flox/flox Pkm2 flox/flox mice, and PCR genotyping of the Pkm2 allele in tumors arising in each condition is shown. Analysis of tail DNA from Pkm2 +/+ and Pkm2 flox/flox mice is shown as a control. b Tumor penetrance in Apc flox/flox Pkm2 +/+ and Apc flox/flox Pkm2 flox/flox mice was determined by colonoscopy. The fraction of mice with tumors did not differ significantly between cohorts at 3 weeks post-infection, at 6 weeks post-infection, or at final inspection (n = 24 Pkm2 flox/flox mice, 28 Pkm2 +/+ mice per cohort, p > 0.1 at all time points, Fisher’s exact test). c Apc flox/flox Pkm2 flox/flox mice had similar tumor multiplicity when compared to Apc flox/flox Pkm2 +/+ mice. Multiplicity is defined as the number of tumors per tumor-bearing animal (n = 17 Pkm2 flox/flox mice, 18 Pkm2 +/+ mice, p > 0.25). d Kaplan-Meier curve showing survival of the Apc flox/flox Pkm2 +/+ and Apc flox/flox Pkm2 flox/flox cohorts. Pkm2 deletion had no statistically significant effect on survival (n = 24 Pkm2 flox/flox mice, 28 Pkm2 +/+ mice per cohort, p = 0.7060, Log-rank (Mantel-Cox) test)

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