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Fig. 1 | Cancer & Metabolism

Fig. 1

From: PKM2 is not required for colon cancer initiated by APC loss

Fig. 1

PKM2 is expressed in colon epithelial cells where loss of APC results in tumor formation. a FFPE colon tissue sections from mice were stained with hematoxylin and eosin (H&E) and isoform-specific antibodies against PKM2 or PKM1 as shown. Scale bars represent 50 μm for all images at ×20 magnification (left) and 20 μm for all images at ×40 magnification (right). b Adenoviral Cre was used to induce colon tumors, with ligation-restricting adenoviral Cre exposure to the distal colon. Lesion appearance and tumor progression were monitored by serial colonoscopy as shown. Representative tumors from four different Apc flox/flox Pkm2 flox/flox mice are shown at various stages of progression

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