Fig. 4
From: Molecular features that predict the response to antimetabolite chemotherapies
Combined gene expression signatures of response to 5-FU across colon cancer cell lines identify novel subgroups. a Schematic of the step-wise filtering used for gene selection in colon cancer (COSMIC COAD-READ). b Hierarchical clustering of heatmap of the discretized gene favorability scores. Columns represent genes and rows represent individuals. Favorable scores are shown by the color red (F = 1), unfavorable by blue (F = − 1), and neutral by yellow (F = 0) (see the “Methods” section). c Box-plots comparing the resistance to 5-FU (log IC-50 values) between the two cell line subgroups identified in part (b) (error bars show the range of the data points in each group)