Fig. 3
From: Molecular features that predict the response to antimetabolite chemotherapies
Combined gene expression signatures of response to Gemcitabine in pancreatic cancer identify novel subgroups. a Schematic of the step-wise filtering used for gene selection in pancreatic cancer (TCGA PAAD). b Hierarchical clustering of heatmap of the discretized gene favorability scores. Columns represent genes and rows represent individuals. Favorable scores are shown by the color red (F = 1), unfavorable by blue (F = − 1), and neutral by yellow (F = 0) (see the “Methods” section). c Pathways enriched in the unfavorable gene set. Enrichment p values are calculated using Fisher’s exact test. d Kaplan-Meier plot showing the progression free survival in the two tumor subgroups identified in part (b)