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Fig. 1 | Cancer & Metabolism

Fig. 1

From: Molecular features that predict the response to antimetabolite chemotherapies

Fig. 1

Combined gene expression signatures of response to 5-FU in colon cancer identify novel subgroups. a Schematic of the step-wise filtering used for gene selection in colon cancer (TCGA COAD). b Hierarchical clustering of heatmap of the discretized gene favorability scores. Columns represent genes and rows represent individuals. Favorable scores are shown by the color red (F = 1), unfavorable by blue (F = − 1), and neutral by yellow (F = 0) (see the “Methods” section). c Pathways enriched in the unfavorable gene set. Enrichment p values are calculated using Fisher’s exact test (see the “Methods” section)

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