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Table 1 Quantitative histological analysis of viable areas of tumour sections (control and β-OHB treated) stained for CD31 (microvessel density as number of vessels/mm2), Ki-67 (proliferative index as % positive cells), cleaved caspase 3 and TUNEL (percent positively stained area)—see Fig. 6. Values are mean ± SEM

From: The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox

 

CD31 (microvessel density: vessels/mm2)

Ki-67 Index (% positive cells)

CC3 (% positively stained area)

TUNEL (% positively stained area)

Control (N = 7)

97.2 ± 12.2

28.9 ± 4.0

1.54 ± 0.36

3.30 ± 1.08

β-OHB treated (N = 8)

133.2 ± 18.0

21.7 ± 3.9

0.83 ± 0.26

2.55 ± 1.40

p (t test)

0.13

0.22

0.13

0.69