Fig. 5From: Mitochondrial mutations and metabolic adaptation in pancreatic cancerProposed convergence model of mtDNA mutations driving metabolic adaptation in pancreatic cancer. We propose a model in which the underlying nuclear genomic landscape of pancreatic cancer cells induces a metabolic challenge. As an adaptation to increased biosynthetic requirements, tumours attenuate oxidative phosphorylation through positive selection for diverse somatic mitochondrial mutations, which converge on common metabolic phenotypesBack to article page