Fig. 3
From: Mitochondrial mutations and metabolic adaptation in pancreatic cancer
Metabolomics analysis of pancreatic cancer PDCLs. a Partial least squares discrimination analysis (PLS-DA) of metabolomics profiles from all pancreatic cell lines (normal and PDCL) used in this study. b Relative intracellular metabolite levels for 13 pancreatic PDCLs and normal HPDE pancreatic cell line grown in two different media (K-SFM and M199/F12). Colour key (top right) is superimposed by a histogram showing counts of all identified metabolites (Z-score). Rows list the identified metabolite names, and columns list the pancreatic cell lines arranged according to hierarchical clustering analysis. c Heirarchical clustering analysis of changes in intracellular metabolite levels for 13 pancreatic PDCLs relative to HPDE normal cells (in K-SFM media). Fold change of metabolites with significantly different levels by ANOVA (p < 0.05) are shown. d Succinate abundance in PDCLs and HPDE (normalised to protein content)