Parameters | C57BL/6J HFD | |||||||
---|---|---|---|---|---|---|---|---|
HFD-HFD Ctrl | HFD-HFD DTIC | HFD-HFD Orli | HFD-HFD Orli DTIC | HFD-ND Ctrl | HFD-ND DTIC | HFD-ND Orli | HFD-ND Orli DTIC | |
Body weight (g) | 32.03 ± 1.94 | 32.28 ± 1.70 (p = 0.999) | 26.16 ± 0.71 (p < 0.0001) | 26.48 ± 0.85 (p < 0.0001) | 27.13 ± 0.75 (p < 0.0001) | 26.73 ± 1. 3 (p < 0.0001) | 23.1 ± 1.02 (p < 0.0001) | 22.9 ± 0.92 (p < 0.0001) |
Blood glucose (mg/dl) | 196.17 ± 6.31 | 194.50 ± 6.98 (p = 0.9997) | 146.3 ± 5.99 (p < 0.0001) | 152.33 ± 5.47 (p < 0.0001) | 174.5 ± 4.72 (p < 0.0001) | 177.5 ± 5.05 (p = 0.0001) | 128.83 ± 6.24 (p < 0.0001) | 129.67 ± 7.4 (p < 0.0001) |
Serum TG (mg/dl) | 84.02 ± 2.89 | 84.17 ± 1.15 (p = 0.9999) | 66.03 ± 3.39 (p < 0.0001) | 67.17 ± 2.76 (p < 0.0001) | 68.48 ± 2.25 (p < 0.0001) | 69.15 ± 2.41 (p < 0.0001) | 60.53 ± 3.15 (p < 0.0001) | 61.35 ± 1.28 (p < 0.0001) |
Serum cholesterol (mg/dl) | 120.82 ± 4.20 | 120.54 ± 4.49 (p = 0.9995) | 95.75 ± 4.91 (p < 0.0001) | 97.21 ± 4.22 (p < 0.0001) | 99.50 ± 2.86 (p < 0.0001) | 100.27 ± 3. 5 (p < 0.0001) | 88.64 ± 5.17 (p < 0.0001) | 89.75 ± 4.3 (p < 0.0001) |
Serum LDLc (mg/dl) | 84.86 ± 2.92 | 85.01 ± 1.17 (p = 0.9999) | 66.69 ± 3.42 (p < 0.0001) | 67.84 ± 2.79 (p < 0.0001) | 69.17 ± 2.27 (p < 0.0001) | 69. 84 ± 2.4 (p < 0.0001) | 63.31 ± 3.13 (p < 0.0001) | 62.96 ± 1.24 (p < 0.0001) |
Serum free fatty acids (mM/l) | 2.22 ± 0.08 | 2.20 ± 0.04 (p = 0.9993) | 1.74 ± 0.09 (p < 0.0001) | 1.73 ± 0.04 (p < 0.0001) | 1.81 ± 0.06 (p < 0.0001) | 1.81 ± 0.05 (p < 0.0001) | 1.66 ± 0.08 (p < 0.0001) | 1.64 ± 0.04 (p < 0.0001) |
Serum leptin (ng/ml) | 43.20 ± 2.40 | 43.11 ± 1.65 (p = 0.9999) | 33.74 ± 2.47 (p < 0.0001) | 33.83 ± 2.80 (p < 0.0001) | 35.19 ± 2.49 (p < 0.0001) | 34.54 ± 2.3 (p < 0.0001) | 26.54 ± 1.60 (p < 0.0001) | 25.58 ± 1.38 (p < 0.0001) |
Serum adiponectin (ng/ml) | 3486 ± 273 | 3421 ± 198 (p = 0.9999) | 8204 ± 593 (p < 0.0001) | 8287 ± 304 (p < 0.0001) | 5292 ± 362 (p < 0.0001) | 5133 ± 228 (p < 0.0001) | 9108 ± 550 (p < 0.0001) | 9189 ± 322 (p < 0.0001) |
Serum insulin (μg/l) | 0.3983 ± 0.02 | 0.385 ± 0.016 (p = 0.8701) | 0.269 ± 0.01 (p < 0.0001) | 0.275 ± 0.021 (p < 0.0001) | 0.3066 ± 0.02 (p < 0.0001) | 0.301 ± 0.02 (p < 0.0001) | 0.2570 ± 0.01 (p < 0.0001) | 0.2631 ± 0.01 (p < 0.0001) |
Serum resistin (ng/ml) | 2.25 ± 0.10 | 2.23 ± 0.11 (p = 0.9999) | 1.66 ± 0.08 (p < 0.0001) | 1.60 ± 0.07 (p < 0.0001) | 1.78 ± 0.08 (p < 0.0001) | 1.82 ± 0.10 (p < 0.0001) | 1.19 ± 0.06 (p < 0.0001) | 1.23 ± 0.06 (p < 0.0001) |
Serum IL-6 (pg/ml) | 45.41 ± 2.45 | 44.99 ± 1.58 (p = 0.9999) | 35.45 ± 2.88 (p < 0.0001) | 35.21 ± 2.31 (p < 0.0001) | 36.40 ± 2.79 (p < 0.001) | 35.59 ± 2.38 (p < 0.0001) | 29.25 ± 2.12 (p < 0.0001) | 27.12 ± 1.83 (p < 0.0001) |
Serum TNF-α (pg/ml) | 29.44 ± 1.74 | 28.67 ± 0.99 (p = 0.9708) | 13.78 ± 1.07 (p < 0.0001) | 14.35 ± 0.62 (p < 0.0001) | 15.99 ± 1.73 (p < 0.0001) | 16.17 ± 1.91 (p < 0.0001) | 11.48 ± 1.12 (p < 0.0001) | 10.80 ± 0.79 (p < 0.0001) |