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Table 2 Logistic Global test p values for pathway level associations of metabolic pathways with tumorigenesis, Gleason grade, and lethal disease

From: The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study

Pathway (n genes)

Tumor tissue vs normal tissue (n = 202)

Gleason grade >8 tumors vs Gleason grade 2–7 tumors (n = 404;>8 = 106/2–7 = 298)

Lethal tumors vs. non-lethal tumors (n = 404; L = 113/NL = 291)

Fatty acid metabolism (n = 39)

<1.0 × 10−10

0.03

1.4 × 10−4

Glycolysis/gluconeogenesis (n = 62)

<1.0 × 10−10

1.4 × 10−5

<1.0 × 10−10

Pentose phosphate (n = 27)

<1.0 × 10−10

3.5 × 10−3

8.9 × 10−5

Purine metabolism (n = 157)

<1.0 × 10−10

8.8 × 10−6

1.2 × 10−8

Pyrimidine metabolism (n = 96)

<1.0 × 10−10

7.6 × 10−5

1.9 × 10−7

Oxidative phosphorylation (n = 123)

<1.0 × 10−10

8.3 × 10−5

3.5 × 10−6

TCA (n = 30)

<1.0 × 10−10

0.78

0.21

  1. All tests compare the null model including only age at diagnosis, cohort (PHS, HPFS), year of diagnosis, and BMI at diagnosis to the full model which also includes the genes in the listed pathway. Matching information is dropped for the tumor vs. normal comparison
  2. NL non-lethal, L lethal