Fig. 7From: Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancerWnt signaling influences cancer metabolism through regulation of SLC16A1/MCT-1 expression. a Immunohistochemical staining of human colon tumor samples (β-catenin and MCT-1) shows correlations between nuclear β-catenin and high levels of MCT-1. Middle and bottom rows show higher power images of boxed portions in the row above. b Model of a colorectal tumor with Wnt signaling regulating cancer metabolism through target genes including SLC16A1/MCT-1 expression. Examples of Wnt signaling and metabolic inhibitors currently under clinical development shown in boxed regionsBack to article page