Fig. 5

XAV939 affects colon cancer cell sensitivity to 3-bromopyruvate. a Table of IC₅₀ values for 3-bromopyruvate in SW480, SW620, HCT116, and DLD-1 cells. Cell cultures were pre-treated with or without XAV939 (10 μM) for 48 h prior to the addition of 3-BP. SW480 (b), SW620 (c), HCT116 (d), and DLD1 (e) cells pre-treated with the Wnt inhibitor XAV939 (10 μM) reduces survival compared to without 3-bromopyruvate treatment, except at high concentrations. Graphs shown represent the average of three independent replicates with error bars depicting the SEM (*p value < 0.05; **p value < 0.01; ***p value < 0.001)